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Carbonyl Reductase 1 is Regulated By DNA Topoisomerase

Posted on August 21, 2020 by Manuel

Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta

 

DNA topoisomerase II beta (TOP2B) has a job in transcriptional regulation. Right here, to additional examine transcriptional regulation by TOP2B, we used RNA-sequencing and real-time PCR to analyse the differential gene expression profiles of wildtype and two impartial TOP2B-null pre-B Nalm-6 cell strains, one generated by focused insertion and the opposite utilizing CRISPR-Cas9 gene enhancing.
We recognized carbonyl reductase 1 (CBR1) among the many most importantly downregulated genes in these TOP2B-null cells. Diminished CBR1 expression was accompanied by lack of binding of the transcription elements USF2 and MAX to the CBR1 promoter. We describe attainable mechanisms by which lack of TOP2B ends in CBR1 downregulation. To our information that is the primary report of a hyperlink between TOP2B and CBR1.

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 exercise

DNA topoisomerase II (TOP2) is a significant DNA metabolic enzyme, with vital roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the goal of a category of anticancer medication that poison the DNA-TOP2 transient advanced to generate TOP2-linked DNA double-strand breaks (DSBs). The buildup of DSBs kills tumour cells however also can lead to genome instability. The best way by which topoisomerase exercise contributes to transcription stays unclear.
On this work we’ve got investigated how transcription contributes to TOP2-dependent DSB formation, genome instability and cell dying. Our outcomes show that gene transcription is a crucial supply of abortive TOP2 exercise.
Nevertheless, transcription doesn’t contribute considerably to apoptosis or cell dying promoted by TOP2-induced DSBs. Quite the opposite: transcription-dependent breaks drastically contribute to deleterious mutations and translocations, and might promote oncogenic rearrangements.
fkb-p65
fkb-p65
Importantly, we present that TOP2-induced genome instability is mediated by mutagenic canonical non-homologous end-joining whereas homologous recombination protects cells in opposition to these insults. Collectively, these outcomes uncover mechanisms behind deleterious results of TOP2 abortive exercise throughout transcription, with related implications for chemotherapy.

Alpha-bungarotoxin, CF405s

00002-100ug Biotium 100uG
EUR 193.2
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF680r

9-00003 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF680r

9-00003 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF640r

9-00004 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF640r

9-00004 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a

9-00005 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a

9-00005 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568

9-00006 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568

9-00006 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594

9-00007 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594

9-00007 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633

9-00009 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633

9-00009 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin

00010-1 Biotium 1MG
EUR 201.6
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin

00011 Biotium 500uG
EUR 440.4
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin

00012 Biotium 500uG
EUR 459.6
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)

00013 Biotium 10ST
EUR 500.4
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)

00014 Biotium 10ST
EUR 559.2
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)

00015 Biotium 500uG
EUR 559.2
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)

00016 Biotium 10ST
EUR 627.6
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin

00017 Biotium 500uG
EUR 519.6
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018 Biotium
  • EUR 592.80
  • EUR 193.20
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:

00020 Biotium 1MG
EUR 376.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)

00020-1 Biotium 20ST
EUR 501.6
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:

00021 Biotium 1MG
EUR 412.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)

00021-1 Biotium 20ST
EUR 537.6
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:

00022 Biotium 1MG
EUR 589.2
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)

00022-1 Biotium 20ST
EUR 750
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:

00023 Biotium 1MG
EUR 337.2
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine

00025 Biotium 100uG
EUR 166.8
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543

00026 Biotium 500uG
EUR 592.8
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u

00027 Biotium 300
EUR 414
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin

00028 Biotium 100U
EUR 513.6
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin

00030 Biotium 300U
EUR 414
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin

00032 Biotium 300ST
EUR 414
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin

00033 Biotium 300EU
EUR 414
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M

00034 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M

00034-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP

00036 Biotium 100ug
EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP

00037 Biotium 100ug
EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555

00040 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647

00041 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647

00041-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A

00042 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A

00042-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543

00043 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543

00043-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568

00044 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568

00044-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594

00045 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594

00045-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633

00046 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633

00046-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R

00047 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R

00047-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R

00048 Biotium 300U
EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R

00048-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350

00049 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350

00049-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R

00050 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R

00050-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532

00051 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532

00051-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C

00052 Biotium 300U
EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C

00052-T Biotium 50U
EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680

00053 Biotium 300U
EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680

00053-T Biotium 50U
EUR 176.4
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430

00054 Biotium 300U
EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430

00054-T Biotium 50U
EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440

00055 Biotium 300U
EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440

00055-T Biotium 50U
EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate

00070 Biotium 100ug
EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate

00071 Biotium 100ug
EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate

00072 Biotium 100ug
EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate

00073 Biotium 100ug
EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug
×

DNA methylation repels binding of hypoxia-inducible transcription elements to take care of tumor immunotolerance

Background: Hypoxia is pervasive in most cancers and different illnesses. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription elements (HIFs), however it’s nonetheless an excellent query why cell varieties differ of their transcriptional response to hypoxia.
Outcomes: We report that HIFs fail to bind CpG dinucleotides which are methylated of their consensus binding sequence, each in in vitro biochemical binding assays and in vivo research of differentially methylated isogenic cell strains. Primarily based on in silico structural modeling, we present that 5-methylcytosine certainly causes steric hindrance within the HIF binding pocket.
A mannequin whereby cell-type-specific methylation landscapes, as laid down by the differential expression and binding of different transcription elements underneath normoxia, management cell-type-specific hypoxia responses is noticed. We additionally uncover ectopic HIF binding websites in repeat areas that are usually methylated.
Genetic and pharmacological DNA demethylation, but in addition cancer-associated DNA hypomethylation, expose these binding websites, inducing HIF-dependent expression of cryptic transcripts.
Consistent with such cryptic transcripts being extra liable to trigger double-stranded RNA and viral mimicry, we observe low DNA methylation and excessive cryptic transcript expression in tumors with excessive immune checkpoint expression, however not in tumors with low immune checkpoint expression, the place they’d compromise tumor immunotolerance. In a low-immunogenic tumor mannequin, DNA demethylation upregulates cryptic transcript expression in a HIF-dependent method, inflicting immune activation and decreasing tumor progress.
Conclusions: Our information elucidate the mechanism underlying cell-type-specific responses to hypoxia and counsel DNA methylation and hypoxia to underlie tumor immunotolerance.
Key phrases: Most cancers; Cryptic transcripts; DNA methylation; HIF; Hypoxia; Immunotherapy; Transcription issue binding.

TaNAC69 from the NAC superfamily of transcription elements is up-regulated by abiotic stresses in wheat and recognises two consensus DNA-binding sequences

NAC proteins are one of many largest households of plant transcription elements and have lately been implicated in numerous physiological processes. To elucidate their function in gene regulation, we decided the DNA-binding specificity of a drought- and cold-inducible NAC protein, TaNAC69 from wheat, and analysed its homologues from different species.
Two consensus DNA-binding sequences (spanning 23-24 bp) of TaNAC69 have been recognized by means of binding website choice and each consisted of two half websites. Complete information on the DNA-binding specificity of TaNAC69 have been generated by means of intensive base substitution mutagenesis.
TaNAC69 and its homologue in Arabidopsis, NAP, sharing 75% sequence id within the NAC area, exhibited related DNA-binding specificity. TaNAC69 was capable of homodimerise by means of its NAC area. The NAC area consists of 5 conserved subdomains.
Subdomain mutation confirmed {that a} loss or discount in TaNAC69 dimerisation capability was accompanied with abolition or lower in its DNA-binding exercise. These information counsel that each one subdomains are needed to take care of a useful NAC area construction required for interplay with DNA and dimerisation.

 

Magnetic Beads (DNA) 60 mL

P920-60 101Bio - Ask for price

FFPE Tissue DNA Extraction Kit - Magnetic Beads

K5011450 Biochain 1 kit
EUR 307.2

Control Magnetic Beads

M1302-1 Biovision Ask for price

Streptavidin Magnetic Beads

HY-K0208 MedChemExpress 5 mL
EUR 645.6

Protein A Magnetic Beads

6507-1 Biovision
EUR 314.4

Protein G Magnetic Beads

6517-1 Biovision
EUR 314.4

Protein L Magnetic Beads

6537-1 Biovision
EUR 352.8

Anti-Flag magnetic beads

B26101 Bimake 1 mL
EUR 579.6
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification.

Anti-Flag magnetic beads

B26102 Bimake 5 mL
EUR 1742.4
Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification.

Anti-HA magnetic beads

B26201 Bimake 1 mL
EUR 579.6
Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification.

Anti-HA magnetic beads

B26202 Bimake 5 mL
EUR 1742.4
Description: Anti-HA magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with high quality mouse IgG2b monoclonal antibody, used for co-immunoprecipitation and protein purification.

Anti-Myc magnetic beads

B26301 Bimake 1 mL
EUR 579.6
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-Myc magnetic beads

B26302 Bimake 5 mL
EUR 1742.4
Description: Anti-Myc magnetic beads kit is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody.it is recommended to use for co-immunoprecipitation and protein purification.

Anti-HA Magnetic Beads

HY-K0201 MedChemExpress 1 mL
EUR 334.8

Protein A Magnetic Beads

HY-K0203 MedChemExpress 1 mL
EUR 148.8

Protein G Magnetic Beads

HY-K0204 MedChemExpress 5 mL
EUR 445.2

Anti-Flag Magnetic Beads

HY-K0207 MedChemExpress 1 mL
EUR 570

Protein A/G Magnetic Beads

6527-1 Biovision
EUR 352.8

Protein A/G Magnetic Beads

HY-K0202 MedChemExpress 1 mL
EUR 157.2

Anti-c-Myc Magnetic Beads

HY-K0206 MedChemExpress 5 mL
EUR 1368

Size Selection DNA Beads

20-abx298001 Abbexa
  • EUR 260.40
  • EUR 477.60
  • EUR 1663.20
  • 1 ml
  • 5 ml
  • 60 ml

VAHTS DNA Clean Beads

N411-01 Vazyme 5 ml
EUR 259.2

VAHTS DNA Clean Beads

N411-02 Vazyme 60 ml
EUR 634.8

VAHTS DNA Clean Beads

N411-03 Vazyme 450 ml
EUR 3055.2

Protein A/G/L Magnetic Beads

6547-1 Biovision
EUR 405.6

Protein A/G Magnetic Beads for IP

B23201 Bimake 1 ml
EUR 158.4
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

Protein A/G Magnetic Beads for IP

B23202 Bimake 5 ml
EUR 558
Description: Protein A/G Magnetic Beads for immunoprecipitation (IP) are based on a biological nanosurface technology (S-TEC). Protein A/G coats the surface of super paramagnetic microspheres with high coating density up to 9.3 × 10^13 molecules/cm2. Compared to similar immune magnetic beads, our Protein A/G beads display much more antibody binding sites therefore using less magnetic beads per reaction and ultimately achiving greater cost-efficiency. Non-specific binding is reduced to an absolute low eliminating any detectable interference with your IP assays. The large, specific surface area of the beads greatly shortens the adsorption time and achieves complete antibody/antigen adsorption process in 10 minutes and complete total purification and precipitation in just 30 minutes. This product can be used on a wide variety of samples, such as in cell lysates, supernatants collected from cell secretion, serum, ascites, and other immune antigens.

100 BP DNA LADDER, 500UL PER KIT

M-DNA-100BP CORNING 1/pk
EUR 87.6
Description: Bioscience Mol Bio; DNA Ladder

1 KB DNA LADDER, 500UL PER KIT

M-DNA-1KB CORNING 1/pk
EUR 84
Description: Bioscience Mol Bio; DNA Ladder

Magnetic Beads-conjugated Mouse anti DDDDK-Tag mAb

AE037 Abclonal 50 ul
EUR 211.2

FAB & Beads(Ballotini Beads)

MED1042 Scientific Laboratory Supplies PK50
EUR 91.2

Circulating DNA Kit (with Magnetic Stand)

abx098869-50rxns Abbexa 50 rxns
EUR 510

Circulating DNA Kit (with Magnetic Stand)

abx298026-50rxns Abbexa 50 rxns
EUR 510

RNA/DNA Purification Kit (Magnetic Bead)

DA0623 Daan Gene 32 test/kit Ask for price

Blood Genomic DNA Kit (with Magnetic Stand)

abx098867-50rxns Abbexa 50 rxns
EUR 360

Viral DNA / RNA Kit (with Magnetic Stand)

abx098871-50rxns Abbexa 50 rxns
EUR 477.6

Viral DNA/RNA Kit (with Magnetic Stand)

abx298029-50rxns Abbexa 50 rxns
EUR 477.6

Latex Beads

abx291003-1L Abbexa 1 L
EUR 2798.4

RNA Beads

20-abx298002 Abbexa
  • EUR 260.40
  • EUR 477.60
  • EUR 1663.20
  • 1 ml
  • 5 ml
  • 60 ml

Bulk Beads

D1131-01 Benchmark Scientific 1 PC
EUR 285.76

Bulk Beads

D1131-05 Benchmark Scientific 1 PC
EUR 285.76

Bulk Beads

D1131-10 Benchmark Scientific 1 PC
EUR 492.47

Bulk Beads

D1132-01TP Benchmark Scientific 1 PC
EUR 492.47

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D1132-05TP Benchmark Scientific 1 PC
EUR 492.47

Bulk Beads

D1132-10TP Benchmark Scientific 1 PC
EUR 492.47

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D1132-15TP Benchmark Scientific 1 PC
EUR 492.47

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D1132-30TP Benchmark Scientific 1 PC
EUR 492.47

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D1132-60 Benchmark Scientific 1 PC
EUR 289.93

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D1133-28 Benchmark Scientific 1 PC
EUR 112.45

Exorose Beads

EXOB-100 ABTBeads 100 ml
EUR 127.2

Exorose Beads

EXOB-25 ABTBeads 25 ml
EUR 69.6

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EXOB-250 ABTBeads 250 ml
EUR 225.6

Saline & Beads

MED1064 Scientific Laboratory Supplies PK50
EUR 91.2

Streptavidin-Sepharose Beads

6565-10 Biovision
EUR 836.4

Streptavidin-Sepharose Beads

6565-100 Biovision Ask for price

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6565-2 Biovision
EUR 274.8

Streptavidin-Sepharose Beads

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EUR 483.6

EZEnrich? Polyubiquitin Beads

6568-300 Biovision
EUR 444

Thrombin Sepharose Beads

7925-1 Biovision
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7925-25 Biovision
EUR 2114.4

Thrombin Sepharose Beads

7925-5 Biovision
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Plasmin Sepharose Beads

7926-1 Biovision
EUR 261.6

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7926-25 Biovision
EUR 2114.4

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Urokinase Sepharose Beads

7927-1 Biovision
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Immobilized Catalase Beads

7931-1 Biovision
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Calmodulin-Sepharose Beads

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EUR 405.6

Refill Glass Beads

B1201-BEAD Benchmark Scientific 1 PC
EUR 141.34

V5 agarose beads

AE029-100ul Abclonal 100 ul Ask for price

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AE029-200ul Abclonal 200 ul
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V5 agarose beads

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AE029-50ul Abclonal 50 ul Ask for price

Glass Beads 0.1mm

GB01 Next Advance 1pack
EUR 129.6
Description: Glass beads. 0.1mm. 1 lb. Non-sterile.

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GB05 Next Advance 1pack
EUR 123.6
Description: Glass beads. 0.5mm. 1 lb. Non-sterile.

Glass Beads 1.0mm

GB10 Next Advance 1pack
EUR 123.6
Description: Glass beads. 1.0mm. 1 lb. Non-sterile.

Sodium hydroxide, Beads

SB6789 Bio Basic 500g
EUR 73.21

RanBP1 Agarose Beads

STA-421 Cell Biolabs 400 µg
EUR 686.4
Description: RanBP1 Agarose Beads selectively pull down the active form of Ran. Beads are colored to allow for a visual check. These are the same beads supplied with our Small GTPase Activation Assays. 400 µg.

Protect beads green

SWA1151 Scientific Laboratory Supplies PK80
EUR 103.74

Protect Beads White

SWA1155 Scientific Laboratory Supplies PK80
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Protect Beads Blue

SWA1158 Scientific Laboratory Supplies PK80
EUR 103.74

Calibration Beads for MoFlo

B28479 Spherotech
EUR 346.8
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

VAHTS mRNA Capture Beads

N401-01 Vazyme 24 rxn
EUR 171.6

VAHTS mRNA Capture Beads

N401-02 Vazyme 96 rxn
EUR 306

VAHTS RNA Clean Beads

N412-01 Vazyme 5 ml
EUR 286.8

VAHTS RNA Clean Beads

N412-02 Vazyme 40 ml
EUR 495.6

VAHTS RNA Clean Beads

N412-03 Vazyme 450 ml
EUR 4860

Stainless Steel Beads 0.2mm

SSB02 Next Advance 1pack
EUR 229.2
Description: Stainless steel beads. 0.2mm. 1 lb. Non-sterile.

Stainless Steel Beads 0.5mm

SSB05 Next Advance 1pack
EUR 229.2
Description: Stainless steel beads. 0.5mm. 1 lb. Non-sterile.
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Recent Posts

  • All types of Research and Publication (including in Diabetes) have shown a healthy rising trend from India in the last decade
  • Cepheid GeneXpert NATtrol
  • Forkhead transcription factor O1 (FoxO1) in torafugu pufferfish Takifugu rubripes: Molecular cloning, in vitro DNA binding, and target gene screening in fish metagenome
  • A Simple Fluorescence Microplate Assay to Monitor RNA-DNA Hybrid Unwinding by the Bacterial Transcription Termination Factor Rho
  • MYB_SH[AL]QKY[RF] transcription factors MdLUX and MdPCL-like promote anthocyanin accumulation through DNA hypomethylation and MdF3H activation in apple
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