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Carbonyl Reductase 1 is Regulated By DNA Topoisomerase

Posted on August 21, 2020 by Manuel

Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta

 

DNA topoisomerase II beta (TOP2B) has a job in transcriptional regulation. Right here, to additional examine transcriptional regulation by TOP2B, we used RNA-sequencing and real-time PCR to analyse the differential gene expression profiles of wildtype and two impartial TOP2B-null pre-B Nalm-6 cell strains, one generated by focused insertion and the opposite utilizing CRISPR-Cas9 gene enhancing.
We recognized carbonyl reductase 1 (CBR1) among the many most importantly downregulated genes in these TOP2B-null cells. Diminished CBR1 expression was accompanied by lack of binding of the transcription elements USF2 and MAX to the CBR1 promoter. We describe attainable mechanisms by which lack of TOP2B ends in CBR1 downregulation. To our information that is the primary report of a hyperlink between TOP2B and CBR1.

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 exercise

DNA topoisomerase II (TOP2) is a significant DNA metabolic enzyme, with vital roles in replication, transcription, chromosome segregation and spatial organisation of the genome. TOP2 is the goal of a category of anticancer medication that poison the DNA-TOP2 transient advanced to generate TOP2-linked DNA double-strand breaks (DSBs). The buildup of DSBs kills tumour cells however also can lead to genome instability. The best way by which topoisomerase exercise contributes to transcription stays unclear.
On this work we’ve got investigated how transcription contributes to TOP2-dependent DSB formation, genome instability and cell dying. Our outcomes show that gene transcription is a crucial supply of abortive TOP2 exercise.
Nevertheless, transcription doesn’t contribute considerably to apoptosis or cell dying promoted by TOP2-induced DSBs. Quite the opposite: transcription-dependent breaks drastically contribute to deleterious mutations and translocations, and might promote oncogenic rearrangements.
fkb-p65
fkb-p65
Importantly, we present that TOP2-induced genome instability is mediated by mutagenic canonical non-homologous end-joining whereas homologous recombination protects cells in opposition to these insults. Collectively, these outcomes uncover mechanisms behind deleterious results of TOP2 abortive exercise throughout transcription, with related implications for chemotherapy.

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Alpha-Bungarotoxin, CF®405S, 500 ug

00002 Biotium 1UG
EUR 527
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-bungarotoxin, CF405s

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EUR 594
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF®405S, 500 ug

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EUR 527

Alpha-Bungarotoxin, CF®405S 100ug

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EUR 132
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

9-00003 Biotium
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  • 500uG
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®680R, 500 ug

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EUR 527

Alpha-Bungarotoxin, CF®680R 100ug

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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®640R, 500 ug

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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

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EUR 527

Alpha-Bungarotoxin, CF®640R 100ug

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  • 500uG
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

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  • 500uG
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®488A, 500 ug

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EUR 527

Alpha-Bungarotoxin CF®488A 100ug

9-00005 Biotium
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  • 500uG
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

9-00006 Biotium
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  • 500uG
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®568, 500 ug

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EUR 527

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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

9-00007 Biotium
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®594, 500 ug

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EUR 527

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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®633, 500 ug

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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

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EUR 527

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  • 500uG
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Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

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0001-PP-001 IBT Bioservices 1 cell line (can order x amount)
EUR 12000
Description: SARS-CoV-2 GFP reporter cell line using HEK293T (ACE2/TMPRSS2) cells

Alpha-Bungarotoxin, 1 mg

00010-1 Biotium 1MG
EUR 193
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, 1 mg

00010-1-1 Biotium EA
EUR 193

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011 Biotium 500uG
EUR 376
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-Alpha-Bungarotoxin, 500 ug

00011-1 Biotium EA
EUR 376

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012 Biotium 500uG
EUR 394
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-Alpha-Bungarotoxin, 500 ug

00012-1 Biotium EA
EUR 394

Fluorescein-alpha-bungarotoxin, 10x50ug

00013 Biotium 10ST
EUR 436
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Fluorescein-alpha-bungarotoxin, 10x50ug

00013-1 Biotium EA
EUR 436

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014 Biotium 10ST
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Tetramethylrhodamine-A-Bungarotoxin, 10x50 ug

00014-1 Biotium EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015 Biotium 500uG
EUR 494
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 500 ug

00015-1 Biotium EA
EUR 494

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016 Biotium 10ST
EUR 560
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Sulforhodamine 101-Alpha-Bungarotoxin, 50 ug

00016-1 Biotium EA
EUR 560

Biotin-XX-A-Bungarotoxin, 500 ug

00017 Biotium 500uG
EUR 455
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Biotin-XX-A-Bungarotoxin, 500 ug

00017-1 Biotium EA
EUR 455

Alpha-Bungarotoxin, CF®555, 500 ug

9-00018 Biotium
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  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Alpha-Bungarotoxin, CF®555, 500 ug

00018-1 Biotium EA
EUR 527

Alpha-Bungarotoxin, CF®555 100ug

9-00018 Biotium
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  • 500uG
  • 100ug
Description: Alpha-bungarotoxin from Krait snake venom (Bungarus multicinctus)

Acrylamide, Chemzymes Ultra Pure®

00019-100 Polysciences Europe GmbH 100g
EUR 101.52
Description: 79-06-1
×

DNA methylation repels binding of hypoxia-inducible transcription elements to take care of tumor immunotolerance

Background: Hypoxia is pervasive in most cancers and different illnesses. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription elements (HIFs), however it’s nonetheless an excellent query why cell varieties differ of their transcriptional response to hypoxia.
Outcomes: We report that HIFs fail to bind CpG dinucleotides which are methylated of their consensus binding sequence, each in in vitro biochemical binding assays and in vivo research of differentially methylated isogenic cell strains. Primarily based on in silico structural modeling, we present that 5-methylcytosine certainly causes steric hindrance within the HIF binding pocket.
A mannequin whereby cell-type-specific methylation landscapes, as laid down by the differential expression and binding of different transcription elements underneath normoxia, management cell-type-specific hypoxia responses is noticed. We additionally uncover ectopic HIF binding websites in repeat areas that are usually methylated.
Genetic and pharmacological DNA demethylation, but in addition cancer-associated DNA hypomethylation, expose these binding websites, inducing HIF-dependent expression of cryptic transcripts.
Consistent with such cryptic transcripts being extra liable to trigger double-stranded RNA and viral mimicry, we observe low DNA methylation and excessive cryptic transcript expression in tumors with excessive immune checkpoint expression, however not in tumors with low immune checkpoint expression, the place they’d compromise tumor immunotolerance. In a low-immunogenic tumor mannequin, DNA demethylation upregulates cryptic transcript expression in a HIF-dependent method, inflicting immune activation and decreasing tumor progress.
Conclusions: Our information elucidate the mechanism underlying cell-type-specific responses to hypoxia and counsel DNA methylation and hypoxia to underlie tumor immunotolerance.
Key phrases: Most cancers; Cryptic transcripts; DNA methylation; HIF; Hypoxia; Immunotherapy; Transcription issue binding.

TaNAC69 from the NAC superfamily of transcription elements is up-regulated by abiotic stresses in wheat and recognises two consensus DNA-binding sequences

NAC proteins are one of many largest households of plant transcription elements and have lately been implicated in numerous physiological processes. To elucidate their function in gene regulation, we decided the DNA-binding specificity of a drought- and cold-inducible NAC protein, TaNAC69 from wheat, and analysed its homologues from different species.
Two consensus DNA-binding sequences (spanning 23-24 bp) of TaNAC69 have been recognized by means of binding website choice and each consisted of two half websites. Complete information on the DNA-binding specificity of TaNAC69 have been generated by means of intensive base substitution mutagenesis.
TaNAC69 and its homologue in Arabidopsis, NAP, sharing 75% sequence id within the NAC area, exhibited related DNA-binding specificity. TaNAC69 was capable of homodimerise by means of its NAC area. The NAC area consists of 5 conserved subdomains.
Subdomain mutation confirmed {that a} loss or discount in TaNAC69 dimerisation capability was accompanied with abolition or lower in its DNA-binding exercise. These information counsel that each one subdomains are needed to take care of a useful NAC area construction required for interplay with DNA and dimerisation.

 

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Magnetic Beads for DNA Purification

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Magnetic Beads DNA Extraction Kit (Food)

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Description: Primary Antibodies

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Description: Primary Antibodies

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Anti-Flag magnetic beads

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Anti-Flag magnetic beads

B26102 Bimake 5 mL
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Description: Anti-Flag magnetic beads is based on hydroxyl magnetic beads covalently coupling with mouse IgG1 monoclonal antibody. It is recommended to use for co-immunoprecipitation and protein purification.

Anti-Flag Magnetic Beads

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Description: Protein & Immunology|Protein Purification and isolation

Concanavalin A Magnetic beads

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Description: Primary Antibodies

Magnetic Beads™ Streptavidin

SMB-B01 ACROBIOSYSTEMS 5mg
EUR 250.7
Description: The Streptavidin-Magnetic Beads are 2.8 µm superparamagnetic particles covalently coupled to a highly pure form of streptavidin (SA). The beads can be used to capture the biotinylated proteins or other molecules, because Streptavidin (SA) has an extraordinarily high affinity for biotin with a dissociation constant (Kd) on the order of 10−14 mol/L, the Biotinylated molecules can bind to the SA irreversibly.Streptavidin is a tetrameric protein purified from the bacterium Streptomyces avidin, and exhibits high binding affinity for biotin. Able to bind one molecule of biotin with each subunit. Streptavidin (PI=6.0-7.5) has lower level of non-specific binding to various biological components at physiological pH than avidin (PI=7.4), resulting from its isoelectric point (PI).The Streptavidin-Magnetic Beads is easy to capture the biotinylated proteins or other molecules in Chemiluminescence procedures, and the bounded protein have no activity lost, this ready to use products could greatly save your protein coupling time and hassle, and help us get the best performance and highly reproducible results.

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EUR 700
Description: Antibody Application Reagents

Protein A/G Magnetic Beads

6527-1 Biovision each
EUR 352.8

Protein A/G Magnetic Beads

HY-K0202 MedChemExpress 1 mL
EUR 157.2

Protein A/G Magnetic Beads

EA-IP-007M Elabscience Biotech 1mL
EUR 80
Description: Primary Antibodies

Anti-c-Myc Magnetic Beads

HY-K0206 MedChemExpress 5 mL
EUR 1368

Magnetic Beads PCR Cleanup Kit

MC004 Geneaid Biotech each
EUR 3

Magnetic Beads PCR Cleanup Kit

MC048 Geneaid Biotech each
EUR 25

Magnetic Beads PCR Cleanup Kit

MC096 Geneaid Biotech each
EUR 45

Anti-tGFP magnetic beads, 1ml

TA150039 Origene Technologies GmbH 1 ml Ask for price

Anti-tGFP magnetic beads, 5ml

TA150040 Origene Technologies GmbH 5 ml Ask for price

9E10, Anti-Myc Magnetic beads

TA150044 Origene Technologies GmbH 1 ml Ask for price

9E10, Anti-Myc Magnetic beads

TA150045 Origene Technologies GmbH 5 ml Ask for price

Anti-HA (Nanobody) Magnetic Beads

AE109 Abclonal 500μL
EUR 382.59

Anti-GFP (Nanobody) Magnetic Beads

AE079 Abclonal 500μL
EUR 382.59

Anti-Myc (Nanobody) Magnetic Beads

AE107 Abclonal 1000μL
EUR 226.72

Human FAP-coupled Magnetic Beads

MBS-K077 ACROBIOSYSTEMS 10mg
EUR 882.9
Description: The biotinylated FAP protein was conjugated to streptavidin magnetic beads. This pre-coupled magnetic bead product can capture the anti-FAP antibody from various assay systems. The beads are in uniform size, narrow size distribution with large surface area and unique surface coating, which can help you get the best performance and highly reproducible results. This FAP coupled magnetic beads will bring great convenience with minimum non-specific binding and developed protocols. This ready-to-use product could greatly save your time and hassle.

Anti-GFP (Nanobody) Magnetic Beads

E45R13193N EnoGene 500 ul
EUR 570.75

Anti-GFP (Nanobody) Magnetic Beads

MBS9143967-INQUIRE MyBiosource INQUIRE Ask for price

DDDDK-Tag Antibody (Magnetic Beads)

abx005594-100l Abbexa 100 µl
EUR 250

Human CD33-coupled Magnetic Beads

MBC-K008 ACROBIOSYSTEMS 2mg
EUR 2757.7
Description: Human CD33 protein is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259(Accession # P20138-1(R69G)).
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Categories

  • Antibodies
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  • cDNA
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  • DNA Templates
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Recent Posts

  • All types of Research and Publication (including in Diabetes) have shown a healthy rising trend from India in the last decade
  • Cepheid GeneXpert NATtrol
  • Forkhead transcription factor O1 (FoxO1) in torafugu pufferfish Takifugu rubripes: Molecular cloning, in vitro DNA binding, and target gene screening in fish metagenome
  • A Simple Fluorescence Microplate Assay to Monitor RNA-DNA Hybrid Unwinding by the Bacterial Transcription Termination Factor Rho
  • MYB_SH[AL]QKY[RF] transcription factors MdLUX and MdPCL-like promote anthocyanin accumulation through DNA hypomethylation and MdF3H activation in apple
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