The E2F1 transcription issue and RB tumor suppressor are greatest identified for his or her roles in regulating
The expression of genes vital for cell cycle development however, additionally they have transcription-independent features that facilitate DNA restore at websites of injury. Relying on the kind of DNA harm, E2F1 can recruit both the GCN5 or p300/CBP histone acetyltransferases to deposit totally different histone acetylation marks in flanking chromatin.
At DNA double-strand breaks, E2F1 additionally recruits RB and the BRG1 ATPase to transform chromatin and promote loading of the MRE11-RAD50-NBS1 complicated. Knock-in mouse fashions exhibit vital roles for E2F1 post-translational modifications in regulating DNA restore and physiological responses to DNA harm. This evaluation highlights how E2F1 moonlights in DNA restore, thus revealing E2F1 as a flexible protein that recruits lots of the identical chromatin-modifying enzymes to websites of DNA harm to advertise restore that it recruits to gene promoters to manage transcription.
DNA Geminivirus An infection Induces an Imprinted E3 Ligase Gene to Epigenetically Activate Viral Gene Transcription
Flowering crops and mammals encode imprinted genes which might be primarily expressed within the endosperm and placenta in a parent-of-origin method. On this examine, we present that early activation of the geminiviral C2 and C3 genes in Arabidopsis crops, which encode a viral suppressor of RNA interference (RNAi) and a replication enhancer protein, respectively, correlates with transiently vegetative expression of Variant In Methylation 5 (VIM5), an endosperm imprinted gene conserved in numerous plant species.

Plant Genomic DNA Kit |
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20-abx098077 | Abbexa |
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Micro Genomic DNA Kit |
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20-abx098242 | Abbexa |
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Blood Genomic DNA Kit |
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abx098868-50rxns | Abbexa | 50 rxns | EUR 326.4 |
Plant Genomic DNA Kit |
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abx294004-50preps | Abbexa | 50 preps | EUR 477.6 |
Yeast Genomic DNA Kit |
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K1414-250 | Biovision | each | EUR 673.2 |
Yeast Genomic DNA Kit |
|||
K1414-50 | Biovision | each | EUR 379.2 |
Animal Genomic DNA Kit |
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abx294005-100preps | Abbexa | 100 preps | EUR 627.6 |
Animal Genomic DNA Kit |
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abx294005-50preps | Abbexa | 50 preps | EUR 477.6 |
Insect Genomic DNA Kit |
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K1412-250 | Biovision | each | EUR 673.2 |
Insect Genomic DNA Kit |
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K1412-50 | Biovision | each | EUR 379.2 |
Fungal Genomic DNA Kit |
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K1415-250 | Biovision | each | EUR 673.2 |
Fungal Genomic DNA Kit |
|||
K1415-50 | Biovision | each | EUR 379.2 |
Mollusc Genomic DNA Kit |
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K1413-250 | Biovision | each | EUR 673.2 |
Mollusc Genomic DNA Kit |
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K1413-50 | Biovision | each | EUR 379.2 |
Human Brain Genomic DNA |
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X11001 | EpiGentek |
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Bacteria Genomic DNA Kit |
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20-abx098080 | Abbexa |
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Genomic DNA Isolation Kit |
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55R-1362 | Fitzgerald | 50 assays | EUR 462 |
Description: Genomic DNA Isolation Kit for use in the research laboratory |
Genomic DNA Isolation Kit |
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K281-50 | Biovision | each | EUR 326.4 |
Genomic DNA Isolation Kit |
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K2118-50 | ApexBio | 50 assays | EUR 385.2 |
ISOLATE II Genomic DNA Kit |
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BIO-52065 | Bioline | 10 preps | Ask for price |
ISOLATE II Genomic DNA Kit |
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BIO-52066 | Bioline | 50 preps | Ask for price |
ISOLATE II Genomic DNA Kit |
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BIO-52067 | Bioline | 250 preps | Ask for price |
FFPE Tissue Genomic DNA Kit |
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abx098866-50rxns | Abbexa | 50 rxns | EUR 326.4 |
Control Genomic DNA - Rat Male |
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D1434999-G01 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Dog Male |
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D1734999-G01 | Biochain | 100 ug | EUR 170 |
Marine Animal Genomic DNA Kit |
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20-abx098079 | Abbexa |
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Sera-Xtracta Genomic DNA Kit |
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29429140 | Scientific Laboratory Supplies | EACH | EUR 574.8 |
Control Genomic DNA - Mouse Male |
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D1334999-G01 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Rat Female |
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D1434999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Dog Female |
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D1734999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Horse Male |
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D1O34999-G01 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Human Male |
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D1234999-G01 | Biochain | 100 ug | EUR 170 |
AccuRT Genomic DNA Removal Kit |
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G488 | ABM | 200 Reactions | EUR 98.4 |
Control Genomic DNA - Rabbit Male |
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D1834999-G01 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Bovine Male |
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D1B34999-G01 | Biochain | 100 ug | EUR 170 |
Genomic DNA Kit (No RNase A) |
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20-abx098862 | Abbexa |
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Control Genomic DNA - Mouse Female |
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D1334999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Porcine Male |
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D1934999-G01 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Chicken Male |
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D1C34999-G01 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Hamster Male |
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D1H34999-G01 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Horse Female |
|||
D1O34999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Human Female |
|||
D1234999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Rabbit Female |
|||
D1834999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Bovine Female |
|||
D1B34999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Porcine Female |
|||
D1934999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Chicken Female |
|||
D1C34999-G02 | Biochain | 100 ug | EUR 170 |
Control Genomic DNA - Hamster Female |
|||
D1H34999-G02 | Biochain | 100 ug | EUR 170 |
Plant Genomic DNA extraction buffer |
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20-abx098075 | Abbexa |
|
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Bacterial Genomic DNA Isolation Kit |
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K309-100 | Biovision | each | EUR 451.2 |
Genomic DNA Extraction Maxi KitPlant |
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FYG104-10P | Yeastern Biotech | 10 Preps | Ask for price |
Genomic DNA Extraction Maxi KitPlant |
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FYG104-25P | Yeastern Biotech | 25 Preps | Ask for price |
Zenoprep Genomic DNA Purification Kit |
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Z2004-400 | GenDepot | 400 preps | EUR 660 |
Zenoquick Genomic DNA Purification Kit |
|||
Z2003-200 | GenDepot | 200 preps | EUR 757.2 |
Blood Genomic DNA Kit (0.1-20 ml) |
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abx098074-For200mlBlood | Abbexa | For 200 ml Blood | EUR 427.2 |
Blood Genomic DNA Kit (0.1-20 ml) |
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abx098074-For50mlBlood | Abbexa | For 50 ml Blood | EUR 260.4 |
Blood Genomic DNA Kit (5-250 ul) |
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20-abx098078 | Abbexa |
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Genomic DNA Extraction and Purification |
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EP10012 | Neuromics | 100 Tests | EUR 606 |
Genomic DNA Extraction KitAnimal Tissue |
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FYG102-100P | Yeastern Biotech | 100 Preps | Ask for price |
Genomic DNA Extraction KitAnimal Tissue |
|||
FYG102-300P | Yeastern Biotech | 300 Preps | Ask for price |
Genomic DNA Extraction KitAnimal Tissue |
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FYG102-50P | Yeastern Biotech | 50 Preps | Ask for price |
Genomic DNA - Rat Normal Tissue: Lung |
|||
D1434152 | Biochain | 100 ug | EUR 286 |
T-Pro Genomic DNA Midi Kit (20) |
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RB94-NGM020 | T-Pro Biotechnology | 20preps/kit | EUR 266.4 |
T-Pro Genomic DNA Mini Kit (100) |
|||
RB94-NGS100 | T-Pro Biotechnology | 100preps/kit | EUR 255.6 |
Genomic DNA - Rat Normal Tissue: Brain |
|||
D1434035 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Rat Normal Tissue: Heart |
|||
D1434122 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Rat Normal Tissue: Liver |
|||
D1434149 | Biochain | 100 ug | EUR 286 |
Control Genomic DNA - Guinea Pig Male |
|||
D1G34999-G01 | Biochain | 100 ug | EUR 170 |
Genomic DNA - Mouse Normal Tissue: Lung |
|||
D1334152 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Rat Normal Tissue: Kidney |
|||
D1434142 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Rat Normal Tissue: Testis |
|||
D1434260 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Rat Normal Tissue: Thymus |
|||
D1434264 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Plant Normal Tissue: Corn |
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D1634330 | Biochain | 10 ug | EUR 212 |
Genomic DNA - Plant Normal Tissue: Rice |
|||
D1634360 | Biochain | 10 ug | EUR 212 |
Plant Genomic DNA Kit(No RNase A) |
|||
20-abx098863 | Abbexa |
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Blood Genomic DNA Kit (No RNase A) |
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20-abx098864 | Abbexa |
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Genomic DNA - Mouse Normal Tissue: Brain |
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D1334035 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Mouse Normal Tissue: Heart |
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D1334122 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Mouse Normal Tissue: Liver |
|||
D1334149 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Rat Normal Tissue: Stomach |
|||
D1434248 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Plant Normal Tissue: Wheat |
|||
D1634390 | Biochain | 10 ug | EUR 212 |
Control Genomic DNA - Guinea Pig Female |
|||
D1G34999-G02 | Biochain | 100 ug | EUR 170 |
AnaPrep Bacterial DNA Extraction Kit (48) For extracting genomic DNA from bacteria |
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Z1322006 | Biochain | 1 kit (48 extractions) Including all required plastic disposables | EUR 216 |
Rapid Blood Genomic DNA Extraction Kit |
|||
BT4782 | Bio Basic | 50Preps | EUR 91.97 |
Rapid Yeast Genomic DNA Extraction Kit |
|||
BS8227 | Bio Basic | 50Preps | EUR 91.97 |
Genomic DNA - Mouse Normal Tissue: Kidney |
|||
D1334142 | Biochain | 100 ug | EUR 286 |
Genomic DNA - Mouse Normal Tissue: Spleen |
|||
D1334246 | Biochain | 100 ug | EUR 286 |
Control Genomic DNA - Rhesus Monkey Male |
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D1534999-G01 | Biochain | 100 ug | EUR 170 |
We exhibit that VIM5 is a ubiquitin E3 ligase and immediately targets DNA methyltransferases MET1 and CMT3 for degradation by the ubiquitin 26S proteasome proteolytic pathway. An infection with Beet extreme curly high virus induces expression of VIM5 in rosette leaf tissues, probably by the expression of the viral Rep protein, resulting in the early activation of C2 and C3 coupled with decreased symmetric methylation in C2-Three promoter and the onset of illness signs.
These findings present that this small DNA virus recruits a bunch imprinted gene for epigenetic activation of viral transcription. Our work reveals a definite technique of plant pathogens to take advantage of the host equipment to inhibit methylation-mediated protection response in establishing an infection.
DNA-Binding and Transcription Activation by Unphosphorylated Response Regulator AgrR From Cupriavidus metallidurans Concerned in Silver Resistance
Although silver and silver nanoparticles at low concentrations are thought-about secure for human well being, their steadily growing use and related launch in nature just isn’t with out danger since it could outcome within the collection of silver-resistant microorganisms, thus impeding the utilization of silver as antimicrobial agent.
Moreover, elevated resistance to metals could also be accompanied by elevated antibiotic resistance. Inactivation of the histidine kinase and concomitant upregulation of the cognate response regulator (RR) of the AgrRS two-component system was beforehand proven to play an vital function within the elevated silver resistance of laboratory tailored mutants of Cupriavidus metallidurans.
Nonetheless, binding of AgrR, a member of the OmpR/PhoP household of RRs with a conserved phosphoreceiver aspartate residue, to potential goal promoters has by no means been demonstrated. Right here we determine differentially expressed genes within the silver-resistant mutant NA4S in non-selective circumstances by RNA-seq and exhibit sequence-specific binding of AgrR to 6 chosen promoter areas of upregulated genes and divergent operons.
We delimit binding websites by DNase I and in gel copper-phenanthroline footprinting of AgrR-DNA complexes, and set up a excessive decision base-specific contact map of AgrR-DNA interactions utilizing premodification binding interference strategies. We recognized a 16-bp core AgrR binding website (AgrR field) organized as an imperfect inverted repeat of 6 bp (ATTACA) separated by Four bp variable in sequence (6-4-6).
AgrR interacts with two main groove segments and the intervening minor groove, all aligned on one face of the helix. Moreover, a further in part imperfect direct repeat of the half-site could also be noticed barely up and/or downstream of the inverted repeat at some operators. Mutant research indicated that each inverted and direct repeats contribute to AgrR binding in vitro and AgrR-mediated activation in vivo.
From the place of the AgrR field it seems that AgrR might act as a Sort II activator for many investigated promoters, together with optimistic autoregulation. Moreover, we present in vitro binding and in vivo activation with dephosphomimetic AgrR mutant D51A, indicating that unphosphorylated AgrR is the lively type of the RR in mutant NA4S.
ProtoGlow ECL 200ml Kit |
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NAT1010 | National Diagnostics | EACH | EUR 354 |
ProtoGlow ECL 500ml Kit |
|||
NAT1012 | National Diagnostics | EACH | EUR 627.6 |
100G Acrylamide |
|||
NAT1014 | National Diagnostics | 100G | EUR 120 |
500G Acrylamide |
|||
NAT1016 | National Diagnostics | 500G | EUR 261.6 |
1KG Acrylamide |
|||
NAT1018 | National Diagnostics | 1KG | EUR 412.8 |
25G AquaPor LE |
|||
NAT1020 | National Diagnostics | 25G | EUR 132 |
100G AquaPor LE GTAC |
|||
NAT1022 | National Diagnostics | 100G | EUR 250.8 |
500G AquaPor LE GTAC |
|||
NAT1024 | National Diagnostics | 500G | EUR 878.4 |
25G AquaPor ES |
|||
NAT1026 | National Diagnostics | 25G | EUR 152.4 |
100G AquaPor ES |
|||
NAT1028 | National Diagnostics | 100G | EUR 350.4 |
25G AquaPor LM |
|||
NAT1030 | National Diagnostics | 25G | EUR 288 |
100G AquaPor LM |
|||
NAT1032 | National Diagnostics | 100G | EUR 860.4 |
25G AquaPor HR |
|||
NAT1034 | National Diagnostics | 25G | EUR 236.4 |
100G AquaPor HR |
|||
NAT1036 | National Diagnostics | 100G | EUR 592.8 |
25G AquaPor 3:1 |
|||
NAT1038 | National Diagnostics | 25G | EUR 250.8 |
100G AquaPor 3:1 |
|||
NAT1040 | National Diagnostics | 100G | EUR 570 |
25G Bis (Methylene Bis-Acrylamide) |
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NAT1042 | National Diagnostics | 25G | EUR 100.8 |
25G DATD Ultrapure |
|||
NAT1044 | National Diagnostics | 25G | EUR 168 |
250G Glycine |
|||
NAT1046 | National Diagnostics | 250G | EUR 94.8 |
1KG Glycine Ultrapure |
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NAT1048 | National Diagnostics | 1KG | EUR 128.4 |
250G Tris |
|||
NAT1050 | National Diagnostics | 250G | EUR 102 |
1KG Tris Ultrapure |
|||
NAT1052 | National Diagnostics | 1KG | EUR 177.6 |
100G Tricine |
|||
NAT1054 | National Diagnostics | 100G | EUR 120 |
100G Ion Exchange Resin (mixed bed) |
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NAT1056 | National Diagnostics | 100G | EUR 96 |
25G Riboflavin |
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NAT1058 | National Diagnostics | 25G | EUR 96 |
25ML TEMED |
|||
NAT1060 | National Diagnostics | 25ML | EUR 99.6 |
25G Ammonium Persulfate |
|||
NAT1062 | National Diagnostics | 25G | EUR 96 |
100G Ammonium Persulfate |
|||
NAT1064 | National Diagnostics | 100G | EUR 118.8 |
1G Dithiothreitol (DTT) |
|||
NAT1066 | National Diagnostics | 1G | EUR 103.2 |
5G Dithiothreitol (DTT) |
|||
NAT1068 | National Diagnostics | 5G | EUR 183.6 |
50ML 2-Mercaptoethanol |
|||
NAT1070 | National Diagnostics | 50ML | EUR 112.8 |
100G SDS Ultrapure |
|||
NAT1072 | National Diagnostics | 100G | EUR 111.6 |
1KG SDS Ultrapure |
|||
NAT1074 | National Diagnostics | 1KG | EUR 457.2 |
250G Urea |
|||
NAT1076 | National Diagnostics | 250G | EUR 98.4 |
1KG Urea |
|||
NAT1078 | National Diagnostics | 1KG | EUR 138 |
450ML Glycerol Ultrapure |
|||
NAT1080 | National Diagnostics | 450ML | EUR 132 |
200ML Tween 20 Ultrapure |
|||
NAT1082 | National Diagnostics | 200ML | EUR 132 |
1L Tween 20 |
|||
NAT1084 | National Diagnostics | 1L | EUR 169.2 |
200ML Formamide |
|||
NAT1086 | National Diagnostics | 200ML | EUR 111.6 |
500ML Boric Acid |
|||
NAT1088 | National Diagnostics | 500ML | EUR 103.2 |
100G EDTA |
|||
NAT1090 | National Diagnostics | 100G | EUR 94.8 |
500G EDTA |
|||
NAT1092 | National Diagnostics | 500G | EUR 177.6 |
GelDry Film 11 X 12 cm |
|||
NAT1094 | National Diagnostics | PK50 | EUR 100.8 |
25ML Formamide CE |
|||
NAT1096 | National Diagnostics | 25ML | Ask for price |
25ML Glass Bond |
|||
NAT1098 | National Diagnostics | 25ML | EUR 158.4 |
450ML Glass Free |
|||
NAT1100 | National Diagnostics | 450ML | EUR 196.8 |
GelDry Film 22.5 X 22.5 cm |
|||
NAT1102 | National Diagnostics | PK50 | EUR 130.8 |
1L DEPC Treated Water |
|||
NAT1104 | National Diagnostics | 1L | EUR 120 |
Sterling Rapid Silver Stain Kit |
|||
NAT1106 | National Diagnostics | 1KIT | EUR 265.2 |
1L ProtoBlue Safe |
|||
NAT1108 | National Diagnostics | 1L | EUR 159.6 |
4L ProtoBlue Safe |
|||
NAT1110 | National Diagnostics | 4L | EUR 282 |
1L ProtoStain Blue |
|||
NAT1112 | National Diagnostics | 1L | EUR 164.4 |
25ML Nuclistain |
|||
NAT1114 | National Diagnostics | 25ML | EUR 128.4 |
450ML AcrylaGel 30% |
|||
NAT1116 | National Diagnostics | 450ML | EUR 128.4 |
1L AcrylaGel 30% |
|||
NAT1118 | National Diagnostics | 1L | EUR 177.6 |
450ML Bis-AcrylaGel 2% |
|||
NAT1120 | National Diagnostics | 450ML | EUR 98.4 |
1L Bis-AcrylaGel 2% |
|||
NAT1122 | National Diagnostics | 1L | EUR 111.6 |
450ML UreaGel 29:1 Concentrate |
|||
NAT1124 | National Diagnostics | 450ML | EUR 133.2 |
1L UreaGel 29:1 Concentrate |
|||
NAT1126 | National Diagnostics | 1L | EUR 183.6 |
UreaGel 29:1 System 1L Kit |
|||
NAT1128 | National Diagnostics | EACH | EUR 171.6 |
UreaGel 29:1 System 2.2L Kit |
|||
NAT1130 | National Diagnostics | EACH | EUR 253.2 |
450ML SequaGel UreaGel Concentrate |
|||
NAT1132 | National Diagnostics | 450ML | EUR 126 |
1L SequaGel UreaGel Concentrate |
|||
NAT1134 | National Diagnostics | 1L | EUR 160.8 |
SequaGel Sequencing System 1L Kit |
|||
NAT1136 | National Diagnostics | 1KIT | EUR 171.6 |
SequaGel Sequencing System 2.2L Kit |
|||
NAT1138 | National Diagnostics | EACH | EUR 253.2 |
100ML SequaGel Buffer |
|||
NAT1140 | National Diagnostics | 100ML | EUR 80.4 |
200ML SequaGel UreaGel Buffer |
|||
NAT1142 | National Diagnostics | 200ML | EUR 84 |
450ML SequaGel UreaGel-6 |
|||
NAT1144 | National Diagnostics | 450ML | EUR 115.2 |
1L SequaGel UreaGel-6 |
|||
NAT1146 | National Diagnostics | 1L | EUR 151.2 |
450ML SequaGel UreaGel-8 |
|||
NAT1148 | National Diagnostics | 450ML | EUR 115.2 |
1L SequaGel UreaGel-8 |
|||
NAT1150 | National Diagnostics | 1L | EUR 151.2 |
450ML SequaGel UreaGel Diluent |
|||
NAT1152 | National Diagnostics | 450ML | EUR 90 |
1L SequaGel UreaGel Diluent |
|||
NAT1154 | National Diagnostics | 1L | EUR 103.2 |
90ML SequaGel Complete Buffer |
|||
NAT1156 | National Diagnostics | 90ML | EUR 79.2 |